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Oxidative stress in Portuguese children with Down syndrome Background - Individuals with Down syndrome have an accelerated process of ageing which is thought to be associated with oxidative stress

10.1038/nrc.2016.71 6 AmaryM

A new phase of insulin secretion

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In contrast, under antioxidant/low-ROS conditions (such as in certain tumor microenvironments or after treatment with BPC157 in our study), BACH1 becomes stabilized and can switch to promoting angiogenesis by directly activating target genes like VEGF